What is hMG?
Human Menopausal Gonadotropin (hMG) is a hormonal medication derived from the urine of postmenopausal women. It contains two key hormones: follicle-stimulating hormone (FSH) and luteinizing hormone (LH). These hormones play an essential role in stimulating ovulation in women and enhancing sperm production in men, making hMG a critical treatment for infertility.
How It Works
hMG mimics natural reproductive hormones, stimulating the ovaries to develop and release mature eggs in women undergoing assisted reproductive techniques like IVF. In men, it stimulates the testes to increase testosterone production and improve sperm development, supporting fertility enhancement.
Administration
- Form: hMG comes as a lyophilized powder in vials, typically reconstituted with sterile saline before injection.
- Route: It is administered via subcutaneous (under the skin) or intramuscular (into the muscle) injection.
- Frequency: The dosing schedule is tailored to individual needs and is often determined by a healthcare provider based on hormone levels and response to treatment.
Dosage
- Women:
Initial doses usually range between 75–150 IU daily, adjusted as needed based on ovarian response monitored via ultrasound or hormone testing.
- Men:
Dosages typically range from 75–150 IU, given 2–3 times per week, alongside human chorionic gonadotropin (hCG).
Precautions
- Medical History: Inform your healthcare provider about any history of hormonal imbalances, ovarian cysts, thyroid disorders, or adrenal dysfunction.
- Monitoring: Frequent monitoring through blood tests and ultrasounds is essential to avoid complications like Ovarian Hyperstimulation Syndrome (OHSS) in women.
- Allergic Reactions: Rarely, allergic reactions such as rash, swelling, or difficulty breathing can occur. Seek immediate medical attention if these arise.
- Pregnancy Risks: While hMG increases the likelihood of pregnancy, it also raises the chances of multiple births (e.g., twins or triplets).
- Storage: Store unused vials in a cool, dry place, away from light, and discard any remaining solution after 24 hours of reconstitution.
Side Effects
- Common: Injection site pain, bloating, headache, or fatigue.
- Rare: Severe abdominal pain, weight gain, or rapid swelling (possible signs of OHSS).
